five lane mouse rotarod set up (Med Associates Inc)
Structured Review
![Comparison of motor and cognitive functions of unmanipulated WT, C3-, and C4B-deficient mice. Unmanipulated WT, or C3 –/– , or C4B –/– mice were assessed for their performance in <t>Rotarod</t> (A) and Barns maze (B,C) tests as described in Section “2. Materials and methods”. In panel (A) , the time to fall from the rotating rod is shown for WT, or C3 –/– , or C4B –/– mice in the Rotarod test on day 1, day 2, day 3, day 4, and day 5. The mean ± standard error (SE) of time to fall (y-axis) vs. day of training (x-axis) is shown [C3 –/– vs. WT: ** p < 0.01, C4 –/– vs. WT: *** p < 0.001; two-way ANOVA, C4 –/– vs. WT: F (4,16) = 13.90; C3 –/– vs. WT: F (4,16) = 6.439; C4 –/– vs. C3 –/– : not significant; n = 3 mice]. In panels (B,C) , the latency time is shown for WT, or C3 –/– , or C4B –/– mice in the Barns maze test during the training period on day 1, day 2, day 3, and day 4 (B) , and the final trial on day 5 (C) . In panel (B) , the mean ± standard error (SE) of latency time (y-axis) vs. day of training (x-axis) is shown. The indicated difference on day 4 was statistically significant, as determined by one-way ANOVA followed by Tukey post-hoc tests [* p < 0.05 for comparisons C4 –/– vs. WT and C4 –/– vs. C3 –/– on day 4; n = (4 mice × 3 trails) = 12]. In panel (C) , the median with 10%/90% percentiles of individual mice are shown in a box and whisker plot with the mean value indicated by “+”. The indicated differences were statistically significant for the final trial on day 5, as determined by one-way ANOVA followed by Tukey post-hoc tests [** p < 0.01 for comparisons between two groups; F (2,9) = 23.56; n = 4 mice].](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6007/pmc10206007/pmc10206007__fncel-17-1170031-g006.jpg)
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1) Product Images from "Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes"
Article Title: Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes
Journal: Frontiers in Cellular Neuroscience
doi: 10.3389/fncel.2023.1170031
Figure Legend Snippet: Comparison of motor and cognitive functions of unmanipulated WT, C3-, and C4B-deficient mice. Unmanipulated WT, or C3 –/– , or C4B –/– mice were assessed for their performance in Rotarod (A) and Barns maze (B,C) tests as described in Section “2. Materials and methods”. In panel (A) , the time to fall from the rotating rod is shown for WT, or C3 –/– , or C4B –/– mice in the Rotarod test on day 1, day 2, day 3, day 4, and day 5. The mean ± standard error (SE) of time to fall (y-axis) vs. day of training (x-axis) is shown [C3 –/– vs. WT: ** p < 0.01, C4 –/– vs. WT: *** p < 0.001; two-way ANOVA, C4 –/– vs. WT: F (4,16) = 13.90; C3 –/– vs. WT: F (4,16) = 6.439; C4 –/– vs. C3 –/– : not significant; n = 3 mice]. In panels (B,C) , the latency time is shown for WT, or C3 –/– , or C4B –/– mice in the Barns maze test during the training period on day 1, day 2, day 3, and day 4 (B) , and the final trial on day 5 (C) . In panel (B) , the mean ± standard error (SE) of latency time (y-axis) vs. day of training (x-axis) is shown. The indicated difference on day 4 was statistically significant, as determined by one-way ANOVA followed by Tukey post-hoc tests [* p < 0.05 for comparisons C4 –/– vs. WT and C4 –/– vs. C3 –/– on day 4; n = (4 mice × 3 trails) = 12]. In panel (C) , the median with 10%/90% percentiles of individual mice are shown in a box and whisker plot with the mean value indicated by “+”. The indicated differences were statistically significant for the final trial on day 5, as determined by one-way ANOVA followed by Tukey post-hoc tests [** p < 0.01 for comparisons between two groups; F (2,9) = 23.56; n = 4 mice].
Techniques Used: Comparison, Mouse Assay, Whisker Assay